Executive Summary

SMA treatment is rapidly evolving, providing patients with increasing therapeutic options.  However, challenges remain in consistently measuring treatment outcomes and facilitating real-time collaboration among clinicians.  RegenMed Circles offer SMA specialists a platform to collect standardized, compliant real-world data (RWD) from routine clinical practice.  The goal is to generate deeper insights, refine treatment strategies, and ultimately improve outcomes for every individual with SMA.

While potential for data sharing exists, the central aim of RegenMed Circles is to foster clinician-led communities dedicated to accelerating advancements in SMA treatment and promoting clinical excellence.  By participating, clinicians can enhance patient care while benefiting from comprehensive benchmarking tools, peer collaboration, and opportunities for professional development.

Introduction

The spinal muscular atrophy (SMA) treatment landscape has been revolutionized in recent years. From gene therapies and antisense oligonucleotides to small molecule SMN protein enhancers, clinicians now have more therapeutic options available than ever before. However, despite these significant clinical advancements, the infrastructure to systematically collect meaningful, comparative outcome data across these diverse treatments often lags behind.

This limitation hinders the ability of clinicians and researchers to optimize treatment protocols, benchmark effectiveness across different interventions, and contribute robust data to the broader understanding of long-term outcomes in SMA.  RegenMed Circles was established to address this critical need — providing a platform for the SMA community to seamlessly track and analyze patient outcomes at scale.

The Opportunity: Closing The Outcomes Gap

SMA care is increasingly outcome-focused, yet few treatment centers possess real-time, structured insights into their own performance, much less how it compares to others. SMA care teams often face challenges in:

• Standardize outcome tracking across providers and protocols
• Analyze trends over time or across treatment types
• Facilitating knowledge sharing and collaboration on clinical advancements within the SMA community

As individuals with SMA and their families become more informed about outcomes and as payers increasingly require robust data, the necessity for structured, real-world evidence is becoming fundamental — not optional.

We can build your Circle based on your preference of outcomes measurements through the creation of Scoring Formulas, like the ones pictured below, to help you identify treatment outcome trends in SMA.

Regenmed Circles: A Platform For Collaborative Care

RegenMed Circles are secure, collaborative networks that enable clinics to:

• Collect and structure real-world treatment outcomes with zero workflow disruption
• Compare anonymized results with national benchmarks
• Collaborate with peers on protocols, research, and publications
• Keep full ownership and control of their patient data

Each Circle focuses on a specific treatment domain or outcome type.  Physicians can join existing Circles or propose new ones based on their areas of interest.

Real-world evidence is becoming essential — not optional.

Improving Patient Outcomes Through Real-World Evidence

By collecting outcomes data in a structured, longitudinal format, clinics gain powerful tools to improve care:

• Identify top-performing protocols and refine treatment plans
• Enhance cycle prep strategies and optimize timing
• Share de-identified insights across clinical teams
• Track long-term patient success — not just short-term metrics

Circle members receive interactive dashboards, cohort-level reports, and access to collaborative datasets.

These tools empower SMA providers to continuously improve outcomes — without hiring new staff or disrupting care delivery.  See below for some examples of what the platform looks like and how it can be used to assess patient outcomes.

Monetizing Your Real-World Data

In addition to improving care, RegenMed Circles create sustainable revenue through compliant, de-identified data licensing.  Clinics can:

• License aggregate datasets to pharma, device, or digital health partners
• Earn up to 85% of licensing revenue
• Participate in studies that shape future treatment development

Revenue is just the beginning.  Circle participation supports scientific publications, conference presentations, and national recognition for clinical leadership.

Call To Action

Circles give doctors treating Spinal Muscular Atrophy a powerful way to elevate care and lead innovation.  Whether you're optimizing supportive care protocols, or working with disease-modifying therapies — Circles make your outcomes work for you.

Join a growing network of physician-led innovators who are shaping the future of SMA care with real-world evidence.

Visit www.rgnmed.com/circles or contact us to learn how to join or launch your own Circle.

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