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RegenMed is proud to announce that Dr. Dimitrios Tsoukas will act as Principal Investigator for a series of major Physicians-Owned Circles in the fast-evolving field of orthobioligics. These will be the first POCs in Greece. The initial POC Observational Protocol designed by Dr. Tsoukas will generate clinically and statistically significant datasets comparing safety and efficacy of PRP, ADSCs, and BMAC in knee osteoarthritis. His clinical surveys will not only track dosage, injection sites and other key treatment protocol information, but specific products used and delivery approaches. The resulting well-correlated datasets will thus represent substantial value to product manufacturers, payers, researchers, AI models and other licensees. Physician investigators participating in Dr. Tsoukas’s POCs will share 85% of all such license fees. In addition to senior positions in several orthopedic organizations such as ESSKA and ISAKOS, Dr. Tsoukas is the founder of IARMES, which includes other leading orthopedic practitioners in Europe and North America. Moreover, Dr. Tsoukas also teaches and practices in several countries outside of Greece, including Switzerland, Qatar, and the UAE. He is also an Adjunct Professor at the University of Nebraska, Lincoln. As such, RegenMed and Dr. Tsoukas expect to significantly expand international physician participation in his Circles.

Medical societies and advocacy groups (“Sponsors”) can now easily establish a mission-impactful and revenue-producing library of proprietary clinical data registries. This Circles Registry Program will materially advance the Sponsor’s charter goals, ethically generate new funding, and add real value to members.The healthcare data market is valued at $60 bn., growing at 20% per year. The physicians and patients whom medical societies and advocacy groups represent are the fundamental sources of that data. Yet, they receive virtually none of it. Circles Registries unlock that value for them. Read more.‍

Longevity medicine is redefining healthcare by shifting focus from treating disease to proactively extending healthspan — the years of life spent in good health. Grounded in geroscience, which targets the biological mechanisms of aging such as cellular senescence and mitochondrial dysfunction, this emerging field relies on personalized diagnostics and interventions including lifestyle optimization, supplements, and geroprotective drugs like metformin and rapamycin.Yet despite growing interest, longevity medicine faces critical challenges: fragmented data, unvalidated biomarkers, and a lack of large-scale human evidence. This is where real-world evidence (RWE) becomes transformative. RWE captures data from everyday clinical settings, enabling researchers to evaluate interventions across diverse populations and timeframes that randomized trials often cannot reach.RegenMed’s Physicians-Owned Circles (POCs) offer a breakthrough approach to generating validated RWE in longevity medicine. These decentralized, clinician-led data networks allow practitioners around the world to collaborate on observational studies tailored to specific conditions and interventions. Each POC adheres to regulatory standards and supports physicians in collecting actionable, clinically-relevant data with minimal burden.For clinicians, POCs offer benchmarking, professional development, and deeper patient engagement. For industry sponsors, they provide cost-effective, validated datasets that can accelerate regulatory approval and post-market surveillance. For the broader field, POCs build a scalable infrastructure to validate therapies, refine biological age clocks, and personalize treatment protocols.As the longevity industry continues to grow, the integration of validated RWE into clinical and research frameworks is essential. It is the key to moving from theory to practice, from hype to health impact. RegenMed’s model demonstrates how real-world data — when generated ethically and collaboratively — can unlock the full promise of longevity medicine for patients, providers, and society.

In the ever-evolving world of healthcare, innovation is key to delivering exceptional patient care. RegenMed is at the forefront of this revolution, providing physicians with turnkey solutions that streamline processes and enhance outcomes. But how exactly does RegenMed empower physicians? Seamless Integration: RegenMed offers comprehensive solutions that integrate seamlessly into existing workflows, reducing administrative burdens and allowing physicians to focus on what they do best — caring for patients. Cutting-Edge Technology: With advanced tools and technologies, RegenMed enables physicians to stay ahead of the curve, providing the latest treatments and therapies to their patients. Enhanced Patient Outcomes: By leveraging data-driven insights and innovative treatments, RegenMed helps physicians achieve better patient outcomes, improving overall health and well-being. Cost Efficiency: Turnkey solutions from RegenMed are designed to be cost-effective, helping practices manage resources more efficiently without compromising on quality. Continuous Support: RegenMed provides ongoing support and training, ensuring that physicians are always equipped with the knowledge and tools they need to succeed. At RegenMed, we understand the transformative power of Circles. Our platform connects physicians with these innovative solutions, empowering them to deliver the best possible care. Learn more how it works: Physician-Owned Circles (POC) - How It Works

From the CEO2025 promises to be an exciting year for RegenMed. We are welcoming new clients, who will be using Circles to make a real difference in evidence-based healthcare for more people.We have strengthened our senior IT leadership, as we architect Circles 4.0. The Company's Strategic Plan incorporates recursive Al learning from Circles databases, as well as blockchain/tokenization for longitudinal medical records.Our Physicians-Owned Circles are proving to be a major step forward in returning to doctors the value created by their clinical hypotheses and data.RegenMed is in a strong position to disrupt a healthcare data market which is delivering too little clinical value for too few people.Please keep with us on our Latest page. Write to us; we love to hear from our shareholders and our clients - including our future ones.Client NewsDr. Marcus Klingenberg, an internationally recognized orthopedic surgeon, will be acting as a Principal Investigator for four separate Physicians-Owned Circles in the field of micronized adipose tissue therapies for musculoskeletal indications. See more here.We have contracted with a publicly traded biotechnology company to support an open-label, IRB-monitored, clinical trial covering exosome therapy in patients suffering from joint and spine pathologies. Follow our Latest page for more details soon, including investigator recruitment.RegenMed will be partnering with a major U.S. foundation to implement a series of Physicians-Owned Circles for orthopedic, biologies and other musculoskeletal indications. These will cover common pathologies and treatment protocols, as well as rare MSK diseases (such as osteogenesis imperfecta and spinal muscular atrophy.)We look forward to providing more details in the weeks to come.Strengthening Our Information And Technology TeamThe Company is fortunate to have Ms. Laura Prey join as a corporate board member, and Mr. Dolph Courchaine assume the role of Chief Technology and Information Officer. They combine decades of IT design and management experience at some of the largest healthcare providers and insurers in the country.Their guidance is already proving crucial as we prepare the advanced platform architecture and then implementation plan for "Circles 4.0".Physicians-Owned CirclesThe most valuable healthcare data sets are those generated directly by physicians, sharing a common clinical hypothesis and patient cohort.Each POC develops clinically and statistically significant data sets based on a specific anatomical region, pathology, treatment, protocol, and outcomes assessment.POCs are 85% owned by participating physicians, who receive a corresponding percentage of license fees. See here for more information.New WebsiteWe hope you will enjoy our new website. In addition to describing our offerings and value propositions more clearly, it provides a single point of entry for all healthcare constituencies to see how Circles work.Our expanding library of Physicians-Owned Circles is supplemented by a similarly growing library of Private Circles, which may be joined upon Sponsor approval.Our Latest page contains a regularly updated list of white papers, articles, and client news.Stay Tuned...In addition to updates on existing and new clients, upcoming newsletters will provide an overview of our 2025 Strategic Plan, capital-raising initiatives. Circle Hours for POC Members, channel partners, and other items of interest to shareholders and the healthcare community at large.‍